Heath Professional Essentials

Diabetes mellitus is a major world health problem. Treatment and management of diabetics is a very
significant issue for governments, society and both pharmacists and pharmaceutical companies.
Completin” rel=”nofollow”>ing this assignment will help you to gain” rel=”nofollow”>in a deeper understandin” rel=”nofollow”>ing of diabetes mellitus.
The length of this assignment excludin” rel=”nofollow”>ing graphs, figure legends and references should be no more than
1000 words. The % of marks allocated to each section is a guide to the word length for that section.
Where appropriate references should be in” rel=”nofollow”>included usin” rel=”nofollow”>ing the Harvard System cited appropriately in” rel=”nofollow”>in the
text with correct formattin” rel=”nofollow”>ing in” rel=”nofollow”>in the reference list. As a guide a min” rel=”nofollow”>inimum of 4 but no more than about 12
references should be used. You are advised to use references from both primary and secondary
Assignments should be typed and submitted usin” rel=”nofollow”>ing learnonlin” rel=”nofollow”>ine via the Course Website. Graphs must be
thoughtfully in” rel=”nofollow”>incorporated in” rel=”nofollow”>into the text.
Due date/time is 11.00PM June 7
1. Why is the disease given the name diabetes mellitus? How does diabetes mellitus differ from
diabetes in” rel=”nofollow”>insipidus?
(5% of assignment marks)
2. Individuals with the diabetes mellitus are classified in” rel=”nofollow”>into two main” rel=”nofollow”>in groups. What are they and
what is the basis of the classification system used?
(5% of assignment marks)
3. How are patients diagnosed as diabetics? What treatment options are most used to manage this
(20% of assignment marks)
4. What changes in” rel=”nofollow”>in the metabolism of glucose and fat (triglycerides) are observed in” rel=”nofollow”>in this disease?
What symptoms might a diabetic show as a result of these metabolic changes and why do these
(40% of assignment marks)
5. Two overnight fastin” rel=”nofollow”>ing patients, A & B, were each given a dose of 75g of glucose at time zero.
Their blood glucose levels were measured at 0, 30, 60, 90, 120 and 240 min” rel=”nofollow”>inutes after in” rel=”nofollow”>ingestion
of the glucose usin” rel=”nofollow”>ing a glucose specific assay. The brief procedure for this assay is:-
a. Add 5.0 ml of assay reagent to sufficient tubes for the assay
b. Add 0. 1 ml of each glucose standard to a tube of assay reagent
c. Add 0. 1 ml of each test serum to a tube of assay reagent.
d. Mix the contents of each tube and read the absorbance at 625 nm.
The results obtain” rel=”nofollow”>ined are shown in” rel=”nofollow”>in the two tables below.
Table 1 – standards
Glucose standard (mmol/L) Absorbance @ 625 nm
0 0.02
3 0.21
6 0.43
9 0.65
12 0.83
Table 2 – patient results
Time (min” rel=”nofollow”>in) Absorbance-Patient A Absorbance-Patient B
0 0.26 0.47
30 0.51 0.63
60 0.25 0.80
90 0.23 0.76
120 0.24 0.63
240 0.30 0.58
Plot a standard graph of absorbance at 625 nm again” rel=”nofollow”>inst glucose concentration You must use
Determin” rel=”nofollow”>ine the concentration of glucose in” rel=”nofollow”>in each patient serum sample and plot glucose
concentration again” rel=”nofollow”>inst the time over which the samples were obtain” rel=”nofollow”>ined.
Comment on the results for the two patients
(15% of assignment marks)
6. What potential long term problems would a pharmacist need to be aware of when advisin” rel=”nofollow”>ing a
diabetic client?

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