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Pantoprazole is widely used proton pump inhibitor (PPIs) and it is a significant drug in the treatment of acid-related disorders [183] and biliary also effective against Helicobacter biliary infections alone or combined with other drugs, like metronidazole, clarithromycin or amoxicillin [184]. This drug was the first water soluble benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4 – dimethoxy- 2- pyridinyl) methyl] sulfinyl]- 1H- benzimidazole sesquihydrate [185]. A molecule with benzimidazole substitution exhibits potent and long-lasting inhibition of gastric acid secretion by selectively interacting with the gastric proton pump (H+/K+-ATPase) in the parietal cell secretory membrane [183, 186]. The molecular formula is C16H14F2N3NaO4S×1. 5 H2O and molecular weight is 432.4 g/Mol[185]. Because of gradual degradation of pantoprazole sodium during heating, the melting point cannot be accurately determined. It is a white to off-white crystalline powder. The structural formula is: [185] Pantoprazole has numerous advantages compared to its analogues (e.g., Omeprazole and lansoprazole) such as greater stability in a neutral PH environment, specific site of binding, and longer duration of action [187]. In addition, it shows no potential to either induce or inhibit the CYP 450 [183,184, 188]. It is a more selective inhibitor of acid secretion than other proton pump inhibitors [189]. Pantoprazole is used for treatment of erosive esophagitis, or “heartburn” caused by gatroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus. Pantoprazole can also be used to treat Zollinger-Ellison syndrome, a condition where the stomac

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