BIOL3430: Biotechnology

Reading Assignment #5
The Human Genome, a Decade Later

Read the above article and thoughtfully answer the following questions. You should not
use any direct quotes or exact wording from the original work. In science, this is
consider plagiarism and you will be graded accordingly. While we will discuss the article
in class, be advised that your grade for this reading assignment is solely dependent
upon the completeness of your written/typed answers.

1. Why does it take so long to see the downstream effects of sequencing the human
genome?

2. Identify 2 new pieces of information gained from completion of the human genome
project.

3. What single technological contribution has impacted our understanding of the human
genome?

4. Up to this point, how have researchers identified the genes most commonly
associated with disease?

5. Why is this method (#4) problematic?

6. It was previously thought that each human has 0.1% genetic variation from all others.
What is this number thought to be now, and why has it changed?

7. Describe the, otherwise novel, medical applications approach of understanding the
link between disease and genetics.

8. How much would you be willing to pay to have your genome sequenced? How
would this information impact your life?

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