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Treatment Patients with PVD should receive lifelong antiplatelet therapy with aspirin. Aspirin has antithrombotic effects and inhibits platelet aggregration. Other medications in this class include Ticlid, Plavix, and Pletal. Ticlid and Plavix are theinopyridine derivatives that inhibit adenosine diphosphate(ADP) –induced platelet aggregration. Endovascular repair is the treatment of vascular disease from endoluminal(inside the blood vessel) and includes angioplasty, stenting, and radiation therapy. Percutaneous transluminal angioplasty (PTA) is indicated for patients who are limited by their pain or treatment of some arterial occlusive disease and is an invasive procedure. Other adjunctive interventional techniques to treat the iliac, femoral, popliteal, and tibial arteries include the use of lasers, cutting balloons, atherectomy devices, and thermal devices. Surgical management can be performed for debilitating peripheral vascular disease. This include arterial bypass to surgically revascularize. Surgery can be done when a patient has disabling claudication and/or limb-threatening ischemia due to blocked arteries in the lower extremities. Other bypasses include aortoiliac bypass, aortobifemoral bypass, iliac endarterectomy, or iliofemoral bypass, axillofemoral bypass, and femoropopliteal bypass. Amputation may be required for uncontrolled infection, uncontrolled pain, extensive tissue loss, and in cases where revascularization cannot be accomplished. Hyperbaric oxygen therapy is also used an as adjuvant therapy in wound care. It involves intermittent treatment of the entire body with 100% oxygen at 20 times greater than normal atmospheric pressures. It reduces amount of hypoxic leukocyte dysfunction occurring within an area of hypoxia and infection. It provides oxygenation to otherwise ischemia areas and arterial blockage by stimulating growth of new blood vessels.

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