Article: Critique Question

5 ANGPTL4 variants and their haplotype are associated with serum lipid levels the risk of coronary artery disease and ischemic stroke and Atorvastin cholesterol lowering responses. Authors: QianYangl, Rui-XinglYin, Xiao-Li Cao2, Feng Huang1, Yi-Jiang Zhou1 and Wu-Xian Chen1 Yang et al. Nutrition and Metabolism https://doi.org/10.1186/s12986-018-0308-5 MY PICOT QUESTION:What is the effect of daily aspirin regimen versus aspirin with a Statin in reducing recurring strokes in six months? Assignment requirements explain each component of PICOT separately. (example) P: population C: 0: T: Answer the following 10 questions: 1. What statistical test was use? 2. How were type land type 2 errors avoided or minimized? 3. Were the findings statistically significant? How do you know? 4. Was the information about the effects size and precision estimates presented?(meaning confidence intervals) 5. Were the findings adequately summarized, with good use of tables and figures? 6. Were all major findings interpreted and discussed within the context of the prior research (review of literature) and,or the studies theoretical/conceptual framework? How do they relate? 7. Was the issue of clinical significance? 8. Were study limitations discussed, and how did they influence the findings and interpretations? 9. Did the report address the issue of the generalization of the findings? 10. Does the study contribute meaningful evidence that can be used in nursing practice? How can the findings guide, or change nursing practice?    

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