Bioinformatics Discussion Assignment 3

Bioin" rel="nofollow">informatics Discussion Assignment 3 Order Description Suppose you are the Prin" rel="nofollow">incipal Investigator (PI) on a large study aimin" rel="nofollow">ing to identify genetic variants associated with Alzheimer’s Disease. You have collected samples from 2,000 cases, 2,000 controls, and genotyped them usin" rel="nofollow">ing the Illumin" rel="nofollow">ina Infin" rel="nofollow">inium Omni5-4 Kit commercial genotypin" rel="nofollow">ing array. You perform sin" rel="nofollow">ingle SNP association disease analysis, and you do not identify any associations that are statistically significant, after adjustin" rel="nofollow">ing for multiple testin" rel="nofollow">ing. You have spent 5 years, and several million $, on collectin" rel="nofollow">ing and analyzin" rel="nofollow">ing these samples. What does this mean, and what would you do next? Comment on: What could be potential causes (give at least 5) for not fin" rel="nofollow">indin" rel="nofollow">ing any significant associations, and mention potential solutions? How could pathway analysis help your project?