Organic Synthesis Experimental Activity: Enantioselective Aldol Reaction
Watch the following video from the Second Semester Organic Chemistry Lab at Eastern Kentucky University, U.S.
https://youtu.be/PzLgmB6WJrY
- Provide the chemical reaction and mechanism of the enantioselective Aldol reaction being performed in this video.
- Explain what the term “enantioselective” means? Does it mean something different from “enantiospecific”?
- Which enantiomer is being formed preferentially?
- Explain how the reaction is able to be enantioselective?
- What is being used in place of an enol or enolate? Explain the reactivity of this nucleophile in comparison to an enol and enolate using resonance contributors of each.
- Write out the reaction procedure and fill in the following reaction table.
Sample Solution