Obstructive Sleep Apnea and inflammation. Dry powder inhaler and spray drying
This is a dissertation introduction chapter.
Confidentiality is a top priority.
I have below outline that has to be followed strictly
1.1. Obstructive Sleep Apnea
a. Definition
b. Prevalence
c. Risk Factors
d. Complications
e. Previous Treatments
f. Current Treatments
g. Drawbacks
h. Investigational Treatments
i. Knowledge Gap
1.2. Intermittent and Chronic Hypoxia
a. Definition
b. Complications
c. Current Treatment Options
1.3. Inflammation and OSA
a. Inflammatory Biomarkers in OSA
b. Matrix Metalloproteinases
c. MMP-9 Clinical Studies
1.4. Doxycycline
a. Chemical Structure
b. Physicochemical Properties
c. Pharmacoogical Class
d. IC50
e. Doxycycline as an Anti-inflammatory
f. Previous Studies
g. Doxycycline and MMP-9
h. Clinical Studies
1.5. Pulmonary Drug Delivery Route
a. Lung Anatomy
b. Lung Physiology
c. Defenition of Pulmonary Drug Delivery
d. Types of Pulmonary Drug Delivery (systemic vs local)
e. pMDI
f. SMI
g. Neubilizers
h. In vitro models to test pulmonary drug delivery (2D, 3D)
1.6. Dry Powder Inhaler
a. Definition
b. In vitro aerosolization
c. Types of DPIs (single use, resistance to airflow, passive)
d. Methods to make dry powder
e. Previous Studies
1.7. Spray Drying (SD)
a. Definition
b. Uses (large scale, etc)
c. Factors Affecting SD
Sample Solution