Pharmacogenetics in drug Oseltamivir

Write a paper discussing the role of transporter pharmacogenetics in Drug (Oseltamivir) Guidelines: • Search online for research manuscripts on drug transporters for Oseltamivir • Choose one drug transporter that has been reported to have clinically significant polymorphisms. • Explore the effect of this polymorphism on the transporter expression and/or functionality • Explain the extent to which the transporter pharmacogenetics affects ANY aspect of the pharmacokinetics (ADME) of the specific drug substrate of choice General guidelines: • Choose a therapeutic drug which is a substrate to a biological transporter • Choose a transporter with a reported pharmacogenetic variation and explain the genetic change • Choose one or more process of the drug Pharmacokinetics (Absorption, distribution, Metabolism, Excretion) and identify the PK/PD parameters measured • Investigate the effect of these genetic variations on the drug's pharmacokinetic characteristics        

Sample Solution