Respond to the following scenario (Hint: use the pharmgkb website to guide your responses):
1-Before initiating abacavir, an anti-retroviral, for a newly diagnosed HIV positive patient the practitioner orders
HLA-B5701 allele genetic testing. The test confirms that the patient carries the HLA-B5701 allele.
Describe what these results mean.
Should the practitioner prescribe abacavir in this case? If not, state why.
2-A patient is prescribed antiplatelet therapy (clopidogrel) following an acute myocardial infarction (MI). Six
months later, the patient suffers another acute MI. The patient has been adherent to therapy and the
practitioner suspects that clopidrogel may have been ineffective. How might genetic testing have been
beneficial in this case?
3- Identify 2 limitations of pharmacogenomics testing. Explain.
4-Identify 2 ethical concerns of using pharmacogenomics testing. Explain
Samples Solution.