Q1: Can we develop bifunctional small molecules that will couple oncoproteins or other cancer-causing molecules of interest to inactivating processes such as degradation and achieve a tissue-specific loss of function?
Assignment: find in the literature or propose an approach to achieve tumor-specific
degradation of oncogenetic proteins
Caveat: Cereblon and HIF1α are ubiquitously expressed
Q2- How would you use a pulse-chase approach to study RNA stability?
Q3- which autophagy step(s) should be inhibitable by small molecules?
Sample Solution