1-What criteria would be appropriate for choosing a model for testing new drugs for prevention of ischaemia-induced ventricular fibrillation? compare the utility of different models and approaches 2- Describe and explain the rationale behind the current pharmacological treatment of pulmonary arterial hypertension, Also, based on what is known about the pathophysiology of this condition, propose two additional mechanisms, not currently exploited, which might be targeted in order to treat it.
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