Scenario B.T., a 22-year-old man who lives in a small mountain town in Colorado, is highly allergic to dust and pollen. B.T.'s wife drove him to the clinic when his wheezing was unresponsive to fluticasone/salmeterol (Advair) and ipratropium bromide (Atrovent) inhalers, he was unable to lie down, and he began to use accessory muscles to breathe. B.T. is started on 4 L oxygen by nasal cannula and an IV of D5W at 15 mL/hr. He appears anxious and says that he is short of breath.
Blood pressure 152/84 mm Hg Pulse rate 124 beats/min Respiratory rate 42 breaths/min Temperature 100.4 ° F (38.4 ° C)
Arterial Blood Gases pH 7.31 Pa CO2 48 mm Hg HCO 3 26 mmol/L Pa O2 55 mm Hg Sa O2 88%
Medication Orders :
Albuterol 2.5 mg plus ipratropium 250 mcg nebulizer treatment STAT
Albuterol (Ventolin) inhaler 2 puffs q4h
Metaproterenol sulfate (Alupent) 0.4% nebulizer treatment q3h
Fluticasone (Flovent) 250 mcg by MDI twice daily
After several hours of IV and PO rehydration and aerosol treatments, B.T.'s wheezing and chest tightness resolve, and he is able to expectorate his secretions. The physician discusses B.T.'s asthma management with him; B.T. says he has had several asthma attacks over the last few weeks. The physician discharges B.T. with a prescription for oral steroid “burst” (prednisone 40 mg/day × 5 days), fluticasone/salmeterol (Advair) 100/50 mcg two puffs twice daily, albuterol (Proventil) metered-dose inhaler (MDI) two puffs q6h as needed using a spacer, and montelukast (Singulair) 10 mg daily each evening. He recommends that B.T. call the pulmonary clinic for follow-up with a pulmonary specialist. 13. What is the rationale for B.T. being on the oral steroid “burst”
The Rationale for B.T. Being on the Oral Steroid "Burst"
The Rationale for B.T. Being on the Oral Steroid "Burst"
Asthma is a chronic respiratory condition that can lead to inflammation and narrowing of the airways, resulting in symptoms such as wheezing, shortness of breath, and chest tightness. In severe cases, asthma attacks can be life-threatening and require immediate medical intervention. In the case of B.T., a 22-year-old man with a history of recurrent asthma attacks and acute exacerbation, the physician prescribed an oral steroid "burst" of prednisone 40 mg/day for 5 days. This treatment approach aims to address the underlying inflammation in the airways and help improve respiratory function.
Thesis Statement
The use of oral steroid "burst" therapy in asthma management is a critical component in controlling acute exacerbations, reducing airway inflammation, and restoring lung function, thus playing a vital role in improving respiratory outcomes for patients like B.T.
Importance of Oral Steroid "Burst" in Asthma Management
1. Anti-Inflammatory Effects: Oral steroids such as prednisone are potent anti-inflammatory agents that work to reduce swelling and inflammation in the airways. During an asthma exacerbation, the airways become inflamed, leading to symptoms like wheezing and difficulty breathing. The oral steroid "burst" helps to suppress this inflammatory response, allowing the airways to open up and improve airflow.
2. Rapid Onset of Action: Oral steroids have a rapid onset of action compared to inhaled corticosteroids. By taking a high dose of prednisone for a short period, patients like B.T. can achieve quick relief from symptoms and prevent further deterioration of lung function.
3. Prevention of Relapse: Asthma exacerbations can increase the risk of future attacks if not properly managed. The oral steroid "burst" therapy not only helps resolve the current episode but also reduces the likelihood of relapse by addressing the underlying inflammation that contributes to asthma symptoms.
4. Complementary to Maintenance Therapy: While inhaled corticosteroids like fluticasone are essential for long-term asthma control, oral steroids play a crucial role in managing acute exacerbations. The combination of maintenance therapy and oral steroid "burst" helps maintain asthma stability and reduce the frequency of severe attacks.
Conclusion
In conclusion, the rationale for B.T. being on the oral steroid "burst" is grounded in its ability to provide rapid and effective anti-inflammatory action, alleviate acute asthma symptoms, prevent relapse, and complement long-term maintenance therapy. By incorporating oral steroids as part of a comprehensive asthma management plan, healthcare providers can optimize treatment outcomes and enhance the quality of life for patients with asthma. As B.T. continues his journey with asthma management, adherence to prescribed medications, regular follow-up with healthcare providers, and proactive self-management strategies will be key in maintaining asthma control and preventing future exacerbations.