Journal

Order Description
7.1. Risk difference and NNT
Watch this video and then summarize the scientific poin” rel=”nofollow”>ints the doctor raised.

Lin” rel=”nofollow”>ink:

7.2. NNT
The effects of statin” rel=”nofollow”>ins in” rel=”nofollow”>in people aged between 30 and 84 years were in” rel=”nofollow”>investigated usin” rel=”nofollow”>ing a prospective cohort study. Data were taken from the QResearch database, a computerized database of anonymised
longitudin” rel=”nofollow”>inal medical records collected prospectively in” rel=”nofollow”>in primary care. A cohort of patients registered with general practices between 1 January 2002 and 30 June 2008 was used. New users of statin” rel=”nofollow”>ins
were compared with non-users.

The in” rel=”nofollow”>intended effects of statin” rel=”nofollow”>ins was a reduction in” rel=”nofollow”>in the occurence of cardiovascular disease. The number needed to treat for cardiovascular disease over 5 years was 37 (95%CI 24-57) for men. Acute
renal failure was a side effect of statin” rel=”nofollow”>ins: the number needed to harm was 434 (95%CI 284-783) for women and 593 (95%CI 388-1070) for men.

Select one of the statements below, categorize it as true or false and explain” rel=”nofollow”>in why.
7.2. A) The number needed to treat is the number of in” rel=”nofollow”>individuals who need to be treated with statin” rel=”nofollow”>ins over five years for one to experience cardiovascular disease.
7.2. B) The number needed to harm is the number of in” rel=”nofollow”>individuals that would need to be treated with statin” rel=”nofollow”>ins over five years for one more person to experience acute renal failure than would have been
observed if the same number of in” rel=”nofollow”>individuals had not received treatment.
7.2. C) A small number needed to harm is desirable.
7.2. D) The uncertain” rel=”nofollow”>inty of the number needed to treat as an estimate of the population parameter is quantified by the 95% confidence in” rel=”nofollow”>interval.

7.3. A) What does the NNT CI that in” rel=”nofollow”>includes a negative number (in” rel=”nofollow”>in comparison with olanzapin” rel=”nofollow”>ine) imply?
7.3. B) Why is the graph centred on in” rel=”nofollow”>infin” rel=”nofollow”>inity in” rel=”nofollow”>instead of zero?

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