The Double Helix
In this assignment, you will read the assigned book The Double Helix: A Personal Account of the Discovery of the Structure of DNA by James B. Watson and write an original scholarly article in which you perform a thoughtful analysis, critique, or other evaluation of a relevant scientific, methodological, ethical, or historical aspect (or a combination thereof) of the account given in the book on the discovery of the structure of DNA. You are expected to seek out primary literature and other reputable sources to aid in explaining and supporting your argument, and properly reference your sources.
• Identify the structure and function of the normal human genome from the chromosomal/chromatin level down to the molecular level.
• Explain major mechanisms involved in the regulation of gene expression.
• List the major types of genomic variations
• Cite examples of common aberrations that result in both heritable and somatic syndromes and disease.
• Describe the concepts behind the key technologies responsible for recent advances in knowledge about the human genome
• Explain the strategies used for human gene therapies
Sample Solution