Western Civ:Antiquity
Module 4 Discussion 1 (Content): The Carolingian Empire, the Culture of the Middle Ages, and the Crusades
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Overview
In this discussion, we will explore some of the most important characteristics and events of the Middle Ages,
including a brief renaissance, the Crusades, and the rise of medieval monarchies.
Outcomes
- Describe the religious, political, social, and economic characteristics of the Carolingian Empire. (A, B, C, D,
E, F, G, K) - Identify and evaluate the successes and failures of the major personalities of the Early Middle Ages. (A, B,
C, D, E, F, G, K) - Analyze the culture of the Middle Ages including the peasants, the knights and courts, and religious reform
movements. (A, B, C, D, E, F, G, K) - Evaluate the rebirth of commerce and urban society. (A, B, C, D, E, F, G, K)
- Trace the development of medieval monarchies. Discuss their successes and failures. (A, B, C, D, E, F, G,
K)
Sample Solution
The variety CYP3A5*3 allele makes a substitute site for grafting in mRNA, offering ascend to anomalous mRNA, which shows up of a stop codon and a slight to invalid degree of protein articulation. This variety allele is more inescapable than the wild-sort allele (CYP3A5*1) in most of populaces, aside from African Americans, that in whom the wild-type allele prevails. It has been discovered that only those with no short of what one wild-sort allele express immense measures of the proteins in the liver. The CYP3A5*3 variety has been associated with a decline in the various substrates of CYP3As (indinavir and saquinavir) freedom (Mouly et al., 2005 and Anderson et al., 2006). Study done by Mouly et al. (2005) assessed the connection between the degree of leeway for saquinavir and varieties for CYP3A4 and CYP3A5 qualities in solid people. They showed that CYP3A5*1 was associated with a development (2-crease) in the freedom of the drug contrasted and the bearers of the CYP3A5*3 varieties (Moulyetal.,2005). Another >
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